Genuinely felt the difference.
I'd been on my medication for a year before I tried Cofactor. The energy dips I'd been chalking up to the meds started lifting after about three weeks.
Cofactor
Health
Health
Cofactor
Daily liquid cofactors for protocols
FORMULATED FOR
DIETARY SUPPLEMENT2 FL OZ (60 mL)
Cofactor Health
Cofactor PPI
The key micronutrients your PPI protocol quietly depletes — in one daily dropper.
- Formulated for your protocol
- Liquid for fast absorption
- Third-party tested
- Clinically meaningful doses
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When to Take
One full dropper, once a day. Most people take it in the morning with water or their first meal. If you have a sensitive stomach, take it with food.
Description
Daily Liquid Cofactors for Acid-Reducer Protocols
Protocol-specific nutrition designed for people on proton pump inhibitors (PPIs) like omeprazole (Prilosec), esomeprazole (Nexium), lansoprazole (Prevacid), and other acid-reducing medications.
PPIs reduce stomach acid — which is effective for GERD and acid reflux, but also impairs absorption of B12, magnesium, calcium, iron, and vitamin C. Long-term PPI use is well-documented to cause nutrient depletion.
Formulated For
- B12 Support — Vitamin B12 requires gastric acid for absorption; PPIs reduce this directly
- Magnesium Support — PPIs inhibit active magnesium transport in the intestine
- Calcium Support — Acid reduction impairs calcium absorption, increasing bone density concerns
Why Cofactor PPI?
Research published in Therapeutic Advances in Drug Safety confirms PPIs deplete multiple essential nutrients. Cofactor PPI targets exactly those depletions.
This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use.
Ingredients
Full ingredient list and dosages are shown in the Supplement Facts panel within the product image gallery.
Cofactor
Health
Health
CofactorPPI
Daily liquid cofactors for PPI protocols
FORMULATED FOR
GLP-1 protocols
DIETARY SUPPLEMENT2 FL OZ (60 mL)
Inside the formula
Every ingredient earns its place.
No filler, no kitchen-sink labels. Each cofactor is dosed to address a specific, documented gap your protocol creates — at amounts your body can actually use.
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Vitamin B12 (methylcobalamin)1,000 mcg
The active, bioavailable form — supports energy metabolism and nerve health that this protocol can quietly erode.
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Magnesium glycinate200 mg
A gentle, well-absorbed form that supports muscle, sleep, and blood-sugar regulation without the GI upset of cheaper salts.
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Vitamin D3 + K22,000 IU / 90 mcg
Paired so calcium goes to bone, not arteries — foundational support that's hard to get from diet alone.
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Electrolyte blend—
Sodium, potassium, and chloride to offset the fluid and mineral shifts common in the first months of treatment.
Every batch is third-party tested for purity and potency.
How it works
Designed for your protocol — not a generic multivitamin.
Most supplements weren't formulated with your medication in mind. Cofactor is built to fill the specific nutritional gaps your protocol creates.
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Your medication does its job
Modern protocols change how your body absorbs, metabolizes, and stores key micronutrients.
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Specific nutrients get depleted
Documented depletions vary by drug — vitamins, minerals, and metabolic cofactors your body still needs every day.
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Cofactor fills the gap
Liquid daily formulation matched to your exact protocol. Easier to absorb, easier to take, designed for the long haul.
Why people stay
Trusted by thousands on their protocol.
People who take a daily medication shouldn't have to guess about nutrition. Cofactor takes the guesswork out — and they keep coming back.
10,000+
Bottles shipped
4.8★
Average rating
Monthly
Auto-delivery, pause anytime
90-day
Money-back guarantee
It's the first supplement I've actually stuck with — because it was built for exactly what I'm on.
— Verified Cofactor subscriber
Questions, answered
Frequently asked
Can I take this alongside my medication?
Cofactor is formulated to complement your protocol, not interfere with it. Ingredients and dosages are chosen to address the specific micronutrient depletions documented for users of this medication. As with any new supplement, confirm with your healthcare provider — especially if you're on multiple prescriptions.
When during the day should I take it?
One full dropper, once a day. Most people take it in the morning with water or their first meal. If you have a sensitive stomach, take it with food.
How is this different from a regular multivitamin?
Generic multivitamins are formulated for a generic person — not someone whose body chemistry has been altered by a daily medication. Cofactor is built around the documented nutrient gaps your specific protocol creates, at clinically meaningful doses.
When will I notice a difference?
Most customers report changes in energy, digestion, or mood within 2–4 weeks. Full micronutrient repletion takes longer — typically 8–12 weeks of daily use.
What if I switch medications?
Cofactor is protocol-specific. If you move from one medication to another (for example, GLP-1 to metformin), you can switch your subscription to the matching Cofactor product at any time from your account.
Can I pause or cancel?
Yes — pause, skip, or cancel anytime from your account. No phone calls, no pressure.
What customers say
Real results from real protocols.
Finally — a supplement that gets it.
Most multivitamins are a shotgun approach. Cofactor was built for my exact protocol, and it shows in the formula and how I feel.
Easy to take, easy to remember.
Dropper format is way easier than my old pile of pills. Subscription auto-renews so I never run out.
Our promise
90-day money-back guarantee.
Try Cofactor for a full three months. If you don't feel a difference, we'll refund your first order in full — no questions, no return shipment required.
Eligible on first orders only. Subscription pauses or cancels anytime.